Publications by authors named "F Riu"
Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine.
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- Macrocycles, derived from natural products, are important in fighting infectious diseases, particularly malaria and certain tropical parasites.
- Researchers discovered new macrocycles related to hymenocardine that effectively inhibit the growth of these parasites, some being more potent than the existing oral drug miltefosine for visceral leishmaniasis.
- While these new compounds show good cell permeability and potential for oral use, challenges remain regarding their low solubility and metabolic stability, suggesting further optimization is needed to enhance their effectiveness.
Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of the tumor microenvironment (TME). This work aimed to characterize the residual TME composition in 96 TNBC patients using immunohistochemistry and in situ hybridization techniques and evaluate its prognostic implications for partial responders vs.
View Article and Find Full Text PDFIn patients with advanced cancer, it is necessary to detect driver mutations and genetic arrangements. If a mutation is found, targeted therapy may become an option. However, in most patients with advanced cancer, obtaining material can be challenging, and these determinations must be made based on small biopsies or cytologic samples.
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