Publications by authors named "F Riedel"
Purpose: Toxicity to systemic cancer treatment represents a major anxiety for patients and a challenge to treatment plans. We aimed to develop machine learning algorithms for the upfront prediction of an individual's risk of experiencing treatment-relevant toxicity during the course of treatment.
Methods: Clinical records were retrieved from a single-center, consecutive cohort of patients who underwent neoadjuvant treatment for early breast cancer.
T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Accordingly, chemicals that activate an unusually high frequency of T cells, as does the most prevalent metal allergen nickel, are not yet identified in a regulatory context.
View Article and Find Full Text PDFWe report the sudden onset of dyspnea and loss of consciousness and fetal bradycardia in a middle-aged obese nulliparous woman at 39 weeks of gestation during first stage of labor leading to the decision for emergency cesarean section. Still during surgery, the mother underwent cardiac arrest. Transesophageal echocardiography during resuscitation showed right ventricular failure leading to the diagnosis of pulmonary embolism.
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- Preoperative evaluation of axillary lymph nodes is important for determining treatment options in early breast cancer, and this study explored the effectiveness of shear wave elastography (SWE) for staging these lymph nodes.
- The research involved 100 patients, measuring the stiffness of axillary lymph nodes with SWE, and established a cutoff velocity of 2.66 m/s to differentiate between malignant and benign nodes with notable sensitivity and specificity.
- The findings suggest that SWE can enhance the assessment of suspicious axillary lymph nodes, providing a valuable tool for improving biopsy decisions and treatment planning in breast cancer patients.
Article Synopsis
- - Pre-therapeutic histologic diagnosis for suspicious breast issues typically uses image-guided biopsies, but patients on anti-coagulation therapy face potential bleeding risks, and there's no standardized management protocol.
- - A survey conducted among breast health experts revealed that over half believe there’s no standard approach for managing breast biopsies in patients on anti-coagulation or anti-platelet therapy, with differing views on when to discontinue medications.
- - Experts generally consider breast biopsies safe for patients on aspirin or prophylactic heparin, but there’s hesitation around performing them on other medications like DOACs or phenprocoumon, suggesting a need for further guidelines.