Auditory nerve fiber excitability for alternative electrode placement in the obstructed human cochlea: electrode insertion in scala vestibuli versus scala tympani.

. The cochlear implant (CI) belongs to the most successful neuro-prostheses. Traditionally, the stimulating electrode arrays are inserted into the scala tympani (ST), the lower cochlear cavity, which enables simple surgical access.

A simple model considering spiking probability during extracellular axon stimulation.

The spiking probability of an electrically stimulated axon as a function of stimulus amplitude increases in a sigmoidal dependency from 0 to 1. However, most computer simulation studies for neuroprosthetic applications calculate thresholds for neural targets with a deterministic model and by reducing the sigmoid curve to a step function, they miss an important information about the control signal, namely how the spiking efficiency increases with stimulus intensity. Here, this spiking efficiency is taken into account in a compartment model of the Hodgkin Huxley type where a noise current is added in every compartment with an active membrane.

A finite element method framework to model extracellular neural stimulation.

Increasing complexity in extracellular stimulation experiments and neural implant design also requires realistic computer simulations capable of modeling the neural activity of nerve cells under the influence of an electrical stimulus. Classical model approaches are often based on simplifications, are not able to correctly calculate the electric field generated by complex electrode designs, and do not consider electrical effects of the cell on its surrounding. A more accurate approach is the finite element method (FEM), which provides necessary techniques to solve the Poisson equation for complex geometries under consideration of electrical tissue properties.

Impact of electrode position on the dynamic range of a human auditory nerve fiber.

. Electrodes of a cochlear implant generate spikes in auditory nerve fibers (ANFs). While the insertion depth of each of the electrodes is linked to a frequency section of the acoustic signal, the amplitude of the stimulating pulses controls the loudness of the related frequency band.

Polarity Sensitivity of Human Auditory Nerve Fibers Based on Pulse Shape, Cochlear Implant Stimulation Strategy and Array.

Neural health is of great interest to determine individual degeneration patterns for improving speech perception in cochlear implant (CI) users. Therefore, in recent years, several studies tried to identify and quantify neural survival in CI users. Among all proposed techniques, polarity sensitivity is a promising way to evaluate the neural status of auditory nerve fibers (ANFs) in CI users.