Publications by authors named "F Raska"
Introduction: Staphylococcus aureus is a gram-positive, facultatively anaerobic coccus capable of causing infectious diseases in animals and humans. Especially dangerous are multidrug-resistant forms with poor or even no response to available treatments.
Objectives: The study aimed to verify the effect of enzybiotics on the healing of S.
Article Synopsis
- - The rising antibiotic resistance of Staphylococcus spp. highlights the need for effective in vivo models to evaluate new antimicrobial treatments.
- - A comprehensive porcine model was developed to simulate extensive skin and soft tissue damage, facilitating the testing of topical antimicrobial agents through a multi-stage protocol.
- - The model demonstrated persistent infection with Staphylococcus aureus throughout the study, confirming its effectiveness for testing short-acting topical antibiotics.
Background: Specific toxic compounds, such as polycyclic aromatic hydrocarbons (PAHs) and their metabolites, may affect the inhalation injury (INHI) grade, patients' status, and prognosis for recovery. This pilot prospective study aimed to: i) evaluate the suitability of bronchoalveolar lavage (BAL) for determination of PAHs in the LRT and of urine for determination of hydroxylated metabolites (OH-PAHs) in patients with INHI, ii) describe the dynamic changes in the levels of these toxic compounds, and iii) correlate these findings with clinical variables of the patients with INHI.
Methods: The BAL and urine samples from 10 patients with INHI were obtained on Days 1, 3, 5, 7, and 14 of hospitalization, if possible, and PAHs (BAL) and OH-PAHs (urine) were analyzed using chromatographic methods (GC-MS and HPLC).