Specificities and redundancies in the NEL family of bacterial E3 ubiquitin ligases of serovar Typhimurium.

serovar Typhimurium expresses two type III secretion systems, T3SS1 and T3SS2, which are encoded in pathogenicity island 1 (SPI1) and SPI2, respectively. These are essential virulent factors that secrete more than 40 effectors that are translocated into host animal cells. This study focuses on three of these effectors, SlrP, SspH1, and SspH2, which are members of the NEL family of E3 ubiquitin ligases.

Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells.

Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. has two type III secretion systems associated with virulence, one involved in the invasion of host cells and another involved in maintaining an appropriate intracellular niche. SrfJ is an effector of the second type III secretion system.

SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Type III Secretion Effector SlrP.

SlrP is a protein with E3 ubiquitin ligase activity that is translocated by serovar Typhimurium into eukaryotic host cells through a type III secretion system. A yeast two-hybrid screen was performed to find new human partners for this protein. Among the interacting proteins identified by this screen was SNRPD2, a core component of the spliceosome.

Special Issue: Type III Secretion Systems in Human/Animal Pathogenic Bacteria.

Type III secretion systems (T3SSs) are molecular devices that are essential for the communication of many Gram-negative bacteria with their eukaryotic hosts [...

The NEL Family of Bacterial E3 Ubiquitin Ligases.

Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera , , , and , among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets.