Multilayered epithelium may be found in patients with Barrett's epithelium and dysplasia or adenocarcinoma.

To determine if multilayered epithelium (MLE) is a useful prognostic indicator for a benign natural history of Barrett's epithelium, we evaluated endoscopic biopsies from patients with Barrett's epithelium without and with dysplasia and/or adenocarcinoma and from non-Barrett's controls for the presence of MLE. MLE was found in 6% of non-Barrett's controls, 30% of Barrett's patients with no dysplasia, and 14% of Barrett's patients with dysplasia and/or adenocarcinoma. MLE was significantly associated with shorter lengths of Barrett's epithelium in both Barrett's groups.

Prospective evaluation of multilayered epithelium in Barrett's esophagus.

Objective: We recently identified a distinctive type of multilayered epithelium in two patients with Barrett's esophagus, which shows morphological characteristics of both squamous and columnar epithelium. This study was performed to prospectively evaluate the prevalence of multilayered epithelium in patients with Barrett's esophagus.

Methods: Mucosal biopsies were obtained from the squamocolumnar junction (Z-line) of 58 patients with endoscopic evidence of esophageal columnar epithelium and from the gastroesophageal junction in 21 patients without endoscopic evidence of esophageal columnar epithelium.

The renal and urologic complications of inflammatory bowel disease.

: Extraintestinal manifestations of inflammatory bowel disease (IBD) are common. Clinically significant renal/urologic complications occur in 10-15% of patients with IBD. In this article, we review the incidence, pathogenesis, diagnosis, and management of the various renal/urologic complications.

Distribution of cytokeratin markers in Barrett's specialized columnar epithelium.

Background & Aims: The cell of origin for Barrett's epithelium is unknown. A multilayered epithelium within Barrett's epithelium has been noted recently. To investigate the hypothesis that this multilayered epithelium may be a transitional stage between squamous and Barrett's epithelium, cytokeratin immunocytochemistry was used to examine normal squamous, Barrett's, and multilayered epithelium.

Phase II chemoprevention trial of oral fenretinide in patients at risk for adenocarcinoma of the prostate.

Prostate cancer is the most common cancer diagnosed in American men. The need to find effective means of preventing this disease is clear. Vitamin A and its analogues (retinoids) act as transcriptional regulators within the nucleus and have been tested as both preventative and therapeutic agents in human malignancy.