Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line.

Background: The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic blood cells, chondrocytes, and fibroblasts were observed. However, the actual FX-9 molecular mode of action is currently not fully understood.

Evaluation of combination protocols of the chemotherapeutic agent FX-9 with azacitidine, dichloroacetic acid, doxorubicin or carboplatin on prostate carcinoma cell lines.

The isoquinolinamine FX-9 is a novel potential chemotherapeutic agent showing antiproliferative effects against hematologic and prostate cancer cell lines such as B- and T-acute lymphoblastic leukemia and prostate cancer (PC) of different species. Interestingly, FX-9 shows no hemolytic activity and low toxicity in benign adherent cells. The detailed FX-9 molecular mode of action is currently not fully understood.

Isoquinolinamine FX-9 Exhibits Anti-Mitotic Activity in Human and Canine Prostate Carcinoma Cell Lines.

Current therapies are insufficient for metastatic prostate cancer (PCa) in men and dogs. As human castrate-resistant PCa shares several characteristics with the canine disease, comparative evaluation of novel therapeutic agents is of considerable value for both species. Novel isoquinolinamine FX-9 exhibits antiproliferative activity in acute lymphoblastic leukemia cell lines but has not been tested yet on any solid neoplasia type.

Density Propagator for Many-Body Localization: Finite-Size Effects, Transient Subdiffusion, and Exponential Decay.

We investigate charge relaxation in quantum wires of spinless disordered fermions (t-V model). Our observable is the time-dependent density propagator Π_{ϵ}(x,t), calculated in windows of different energy density ϵ of the many-body Hamiltonian and at different disorder strengths W, not exceeding the critical value W_{c}. The width Δx_{ϵ}(t) of Π_{ϵ}(x,t) exhibits a behavior dlnΔx_{ϵ}(t)/dlnt=β_{ϵ}(t), where the exponent function β_{ϵ}(t)≲1/2 is seen to depend strongly on L at all investigated parameter combinations.