Segetalin B Promotes Bone Formation in Ovariectomized Mice by Activating PLD1/SIRT1 Signaling to Inhibit γ-Secretase-Mediated Notch1 Overactivation.

Segetalin B (SB) has shown promise in mitigating osteoporosis in ovariectomized (OVX) mice, though its underlying mechanisms remain unclear. This study investigates how SB promotes bone formation through Phospholipase D1 (PLD1) activation in OVX models. In vitro, bone marrow-derived mesenchymal stem cells (BMSCs) from OVX mice were cultured for osteogenic differentiation.

Transcriptome sequencing and anthocyanin metabolite analysis involved in leaf red color formation of Cinnamomum camphora.

Cinnamomum camphora, a key multifunctional tree species, primarily serves in landscaping. Leaf color is crucial for its ornamental appeal, undergoing a transformation to red that enhances the ornamental value of C. camphora.

Effect of marriage on overweight and obesity: evidence from China.

Background: The number of overweight and obese people in China is showing a rapidly rising trend. Exploring the reasons behind this phenomenon is an urgent academic topic. This study aims to evaluate the effect of marriage on overweight and obesity in China.

phage ΦPNJ-9 adheres to mucus via a variant Hoc protein.

Phages, as antagonists of bacteria, hold significant promise for combating drug-resistant bacterial infections. Their host specificity allows phages to target pathogenic bacteria without disrupting the gut microbiota, offering distinct advantages in the prevention and control of intestinal pathogens. The interaction between the phage and the gut plays a crucial role in the efficacy of phage-mediated bacterial killing.

A Chain Mediation Model of Basic Need Satisfaction and Self-Concept Clarity Between Harsh Parenting and Problematic Internet Use Among Adolescents.

This study presents a model of harsh parenting that has an indirect and direct effect on problematic Internet use (PIU) through the mediating process of basic need satisfaction and self-concept clarity. A sample of 490 Chinese middle-school adolescents completed anonymous questionnaires regarding harsh parenting, PIU, basic need satisfaction, and self-concept clarity during class sessions. After controlling the sex, grade, and history of Internet use, harsh parenting was positively related to PIU.