Publications by authors named "F R Spilki"

Article Synopsis
  • Hepacivirus is an RNA virus genus, with hepatitis C virus (HCV) being the most well-known member, and various hepaciviruses have been found in different rodent species.
  • A new potential genotype of an unclassified rodent hepacivirus was discovered in a wild cavy, indicating that this virus can cross species boundaries, as it was previously identified in a different rodent species.
  • The study's findings, which include complete genome sequencing, could help researchers understand the evolutionary origins of HCV and identify potential virus reservoirs related to human pathogens.
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Domestic cat hepadnavirus (DCH) (Orthohepadnavirus felisdomestici) is an emerging virus related to the hepatitis B virus (HBV) already reported in many countries. The molecular prevalence of DCH varies widely in the regions investigated so far. In the present work, we reported the presence of DCH in Brazil.

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Influenza circulation was significantly affected in 2020-21 by the COVID-19 pandemic. During this time, few influenza cases were recorded. However, in the summer of 2021-22, an increase in atypical influenza cases was observed, leading to the resurgence of influenza in the southernmost state of Brazil, Rio Grande do Sul (RS).

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The COVID-19 pandemic has led to the emergence of acute and chronic post-COVID syndromes, which present diverse clinical manifestations. The underlying pathophysiology of these conditions is not yet fully understood, but genetic instability has been proposed as a potential contributing factor. This study aimed to explore the differential impact of physical and psychological health factors on genetic instability in individuals with acute and chronic post-COVID syndromes.

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Article Synopsis
  • Since 2021, Brazil has faced a surge in COVID-19 cases and deaths due to new variants of concern (VOC) and low vaccination rates, which have led to the emergence of more mutations.
  • The study aimed to assess whether local genomic surveillance and epidemiological data can reflect nationwide trends in the COVID-19 pandemic.
  • Findings revealed three key variant replacements (Gamma, Delta, and Omicron) and highlighted that vaccination became increasingly effective in preventing new cases and deaths as the pandemic progressed.
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