Publications by authors named "F R Seiler"
Target values for arterial carbon dioxide tension (PaCO 2 ) in extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) are unknown. We hypothesized that lower PaCO 2 values on ECMO would be associated with lighter sedation. We used data from two independent patient cohorts with ARDS spending 1,177 days (discovery cohort, 69 patients) and 516 days (validation cohort, 70 patients) on ECMO and evaluated the associations between daily PaCO 2 , pH, and bicarbonate (HCO 3 ) with sedation.
View Article and Find Full Text PDFBackground: The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins may reduce the risk of exacerbations especially in patients with cardiovascular comorbidities.
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- ARDS is a serious condition, impacting over 10% of ICU patients globally with a high mortality rate, making ECMO a potentially vital, but complex, treatment option.
- Recent research analyzed 283 ARDS patients treated with V-V ECMO in Germany, revealing a median age of 56 and an in-hospital mortality rate of about 50.9%.
- While various scoring systems were evaluated for predicting patient outcomes, the study concluded that none, including the Simplified Acute Physiology Score-II, demonstrated strong predictive value for selecting patients suitable for ECMO.
Background: MRproANP and COPAVP are prognostic markers for mortality in chronic obstructive pulmonary disease (COPD). Furthermore, these biomarkers predict mortality due to cardiovascular diseases, which are important prognostically determining comorbidities in patients with COPD. However, less is known about these biomarkers in recently diagnosed mild to moderate COPD.
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- ECMO is a life-saving treatment for patients with severe lung injuries, but sometimes it fails to improve low oxygen levels in the blood.
- Some patients have been treated with a second membrane lung connected either in series (one after the other) or in parallel (side by side) to help with this issue, but it's unclear which method works better.
- Testing showed that using two lungs in a series configuration was 17% more effective at transferring oxygen compared to a parallel setup, but more research is needed before this approach can be widely adopted due to its invasive nature.