Publications by authors named "F R Lopez Andreu"
The anatomic and histologic characteristics of the nipple-areolar complex make this breast region special. The nipple-areolar complex can be affected by abnormal development and a wide spectrum of pathological conditions, many of which have unspecific clinical and radiological presentations that can present a challenge for radiologists. The nipple-areolar complex requires a specific imaging workup in which a multimodal approach is essential.
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- The study aimed to assess how heart rate at admission, discharge, and the difference between the two affects long-term outcomes in acute heart failure patients with either sinus rhythm or atrial fibrillation.
- It included 1398 patients and found that only the heart rate at discharge was linked to one-year mortality, with higher rates indicating a greater risk for both sinus rhythm and atrial fibrillation patients.
- The conclusions suggest that a lower discharge heart rate is associated with better long-term outcomes in these patients, while admission heart rate and the difference didn't show significant prognostic impact.
Background: A population pharmacokinetic (PK) protein-binding model was developed to (1) predict free mycophenolic acid (fMPA) based on total MPA (tMPA) concentrations in renal transplant patients, to establish the therapeutic range of fMPA through pharmacokinetic-pharmacodynamic studies; and (2) provide a guideline for dosing mycophenolate mofetil (MMF).
Methods: Full PK profiles of 56 patients (from five different occasions) during the first year after transplantation who were treated with oral MMF and cyclosporine, or macrolides (either tacrolimus or sirolimus), were analysed. fMPA protein-binding was modelled using nonlinear mixed effects modelling (NONMEM).
Introduction: Tacrolimus (Tac) has a narrow therapeutic window and shows large between-patient pharmacokinetic variability. As a result, over-immunosuppression and under-immunosuppression are frequently encountered in daily clinical practice. Unraveling the impact of genetic polymorphisms on Tac pharmacokinetics may help to refine therapy.
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