[Representations of the SARS-CoV-2 pandemic and confinement in a liberal psychiatric patient base in Paris].

A brief description of attitudes and representations of SARS-Cov-2 pandemic among patients in a psychiatric Parisian office. Collected data suggest that the confinement's measure has been accepted. However the end of confinement has been a time of increased anxiety for many.

Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer.

Designed ankyrin repeat proteins are a novel class of specific binding molecules, which display increased thermodynamic stability, smaller size and at least equal target affinity compared to immunoglobulins, making them potentially powerful tools in diagnostic pathology and therapeutic oncology. Here, we investigated whether designed ankyrin repeat proteins can reliably identify the amplification status of the epidermal growth factor receptor 2 in breast cancer. Designed ankyrin repeat proteins specific for epidermal growth factor receptor 2 were tested in paraffin-embedded tissue sections.

NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration.

NY-ESO-1 is a cancer testis antigen expressed in various malignancies and testicular germ cells. Because of its capacity to induce specific humoral and cellular immunity in patients with NY-ESO-1-positive carcinomas, it represents a promising target for cancer immunotherapy. In breast cancer, NY-ESO-1-mRNA was reported in up to 42%, but protein expression has not been determined to larger extent.

Novel ruthenium(II)2 carboxylates as catalysts for alkene metathesis.

The reactions of [Ru-(=CHR)Cl2(PCy3)2] (1: R = Ph; 1a: R = -CH=CPh2) with silver salts of carboxylic acids afforded new dimeric complexes of the general formula [Ru2(=CHR)2-(R'CO2)2(mu-R'CO2)2(PCy3)2(mu-H2O)] (2: R = Ph, R' = CF3; 3: R = Ph, R' = C2F5; 4: R = -CH=CPh2, R' = CF3; 5: R = Ph, R' = C6F5; 6: R = -CH=CPh2, R' = C6F5; 7: R = -CH=CPh2, R'=CCl3) in good yields. With R' = CF3, C2F5 or CCl3 these complexes are active catalysts for metathesis of acyclic alkenes, including unsaturated fatty acid esters, as well as for ring closing metathesis. The reactivity of these complexes with bases and weak donor solvents has been studied and their half-life times in several media were determined.

[Attitudes and practices of drug users confronted with the risks of contamination by human immunodeficiency virus (HIV) and hepatitis B and C viruses].

This study has been conducted in Lille, Marseille, Metz, Paris and its suburbs using an ethnographic methodology. A total number of 1,703 subjects using injectable drugs have been interviewed in the streets and in treatments centers. The result of the study are as follows: sharing syringes did progressively decrease since 1988; reusing syringes and sharing of the injection equipment maintained itself during the same time period; a decrease of HIV seroprevalence; a massive HVC contamination; qualitative and quantitative data do suggest the important role played by the multiple use of the same syringes and the sharing of the injection equipment.