Publications by authors named "F R David"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFYeast-based sensors have shown great applicability for deorphanization of G protein-coupled receptors (GPCRs) and screening of ligands targeting these. A GPCR of great interest is free fatty acid 2 receptor (FFA2R), for which short-chain fatty acids such as propionate and acetate are agonists. FFA2R regulates a wide array of downstream receptor signaling pathways in both adipose tissue and immune cells and has been recognized as a promising therapeutic target, having been implicated in several metabolic and inflammatory diseases.
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- The study investigates how subthalamic nucleus deep brain stimulation (STN-DBS) surgery affects cognitive aspects of motor control in people with Parkinson's disease (PD) over time.
- Researchers compared participants' saccade latency and reach reaction time before surgery and about 8 months after surgery while off medication and stimulation.
- Results showed that both saccade latency and reach reaction time significantly worsened post-surgery, suggesting negative long-term cognitive impacts from the surgery.
Article Synopsis
- Quality improvement aims to enhance care and patient experience, particularly in palliative care, and can be guided by ethical frameworks and good clinical practices.
- * Palliative care faces unique ethical challenges that can inform quality improvement strategies in other medical specialties, as highlighted by case studies like the Liverpool Care Pathway.
- * Ethical quality improvement practices in palliative care emphasize informed consent, monitoring for vulnerability, and the significant value of time, insisting on beneficence and autonomy to safeguard patients.
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumour growth and is divided into three phases: elimination, equilibrium and escape. The role of NK cells has mainly been attributed to the elimination phase. Here we show that NK cells play a role in all three phases of cancer immunoediting.
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