Publications by authors named "F R Cassee"

Article Synopsis
  • The implementation of Safe and Sustainable by Design (SSbD) and grouping approaches requires effective and cost-efficient assays for early hazard screening, particularly for nanomaterials (NMs).
  • Oxidative potential (OP), indicating a substance’s ability to produce harmful reactive oxygen species (ROS), is a key factor in assessing potential oxidative damage, often measured using the ferric reducing ability of serum (FRAS) assay.
  • A modified 96-well format of the FRAS assay enhances user-friendliness and throughput, allowing for simultaneous screening of multiple NMs, although it shows slightly lower precision than the original cuvette-based method while still maintaining acceptable variability in results.
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The effects of ultrafine particle (UFP) inhalation on neurodevelopment, especially during critical windows of early life, remain largely unexplored. The specific time windows during which exposure to UFP might be the most detrimental remain poorly understood. Here, we studied early-life exposure to clean ultrafine carbonaceous particles (UFP) and neurodevelopment and central nervous system function in offspring.

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The effect of cooking aerosol on the human heart was investigated in this study. The heart rate and blood pressure of 33 healthy adults were monitored before, exactly after, and two hours post-exposure (30 minutes, 60 minutes, 90 minutes, and 120 minutes after cooking). One hundred twenty grams of ground beef was fried in sunflower oil for twenty minutes using a gas stove without ventilation.

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Exposure to traffic-related air pollution and ultrafine particles (<100 nm; UFP) is linked with neurodegeneration. However, the impact of the aromatic content in fuels and the contribution of different fractions of UFP, i.e.

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The domestic combustion of locally sourced smoky (bituminous) coal in Xuanwei and Fuyuan counties, China, is responsible for some of the highest lung cancer rates in the world. Recent research has pointed to methylated PAHs (mPAHs), particularly 5-methylchrysene (5MC), within coal combustion products as a driving factor. Here we describe measurements of mPAHs in Xuanwei and Fuyuan derived from controlled burnings (i.

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