NMR Studies on the Structure of Yeast Sis1 and the Dynamics of Its Interaction with Ssa1-EEVD.

HSP70 chaperones play pivotal roles in facilitating protein folding, refolding, and disaggregation through their binding and releasing activities. This intricate process is further supported by J-domain proteins (JDPs), also known as DNAJs or HSP40s, which can be categorized into classes A and B. In yeast, these classes are represented by Ydj1 and Sis1, respectively.

Exploring the antivirulence potential of phenolic compounds to inhibit quorum sensing in Pseudomonas aeruginosa.

Bacteria coordinate gene expression in a cell density-dependent manner in a communication process called quorum sensing (QS). The expression of virulence factors, biofilm formation and enzyme production are QS-regulated phenotypes that can interfere in human health. Due to this importance, there is great interest in inhibiting QS, comprising an anti-virulence strategy.

Pesticides and violations of human rights to health and food sovereignty in Guarani Kaiowá communities in MS, Brazil.

Brazil, one of the world's largest agricultural producers and consumers of pesticides, has expanded its agricultural area in the southern region of Mato Grosso do Sul, intensifying environmental contamination and increasing the vulnerability of indigenous populations. This research assessed the presence of pesticides in the waters of two indigenous communities in MS, Retomada Guyraroká and Aldeia Jaguapiru. Between 2021 and 2022, three sampling campaigns of surface, supply, and rainwater were conducted, considering the agricultural calendar.

Leptin, NK cells, and the weight of immunity: Insights into obesity.

Obesity is a chronic inflammatory disease that affects more than 1 billion people worldwide and is associated with various metabolic and physiological dysfunctions, directly impacting the dynamics of the immune response, partly due to elevated leptin levels. Leptin is an important peptide hormone that regulates neuroendocrine function and energy homeostasis, with its blood levels reflecting energy reserves, fat mass, or energy deprivation. This hormone also plays a fundamental role in regulating immune function, including the activity of NK cells, which are essential components in antiviral and antitumor activity.