Publications by authors named "F Questel"
Article Synopsis
- Researchers examined the effects of combining prazosin (α1b blocker) and cyproheptadine (5HT2A blocker) on alcohol consumption in individuals with Alcohol Use Disorder (AUD).
- The study involved 154 participants in France, who were divided into three groups for a 3-month trial: low-dose, high-dose, and placebo.
- Results indicated a significant reduction in total alcohol consumption (TAC) for both the low and high-dose groups compared to the placebo, suggesting that this combination therapy is effective and safe for decreasing alcohol intake.
Aim Of The Study: The past twenty years have seen a rise in cocaine-related statistics in France, including cocaine use in the general population, emergency ward presentations of acute cocaine intoxication, cocaine use disorders related outpatient appointments and cocaine-related deaths. This study's objectives were to describe trends in patients' admission for specific cocaine detoxification as well as changes in patients' characteristics in the Assistance publique-Hôpitaux de Paris (AP-HP) hospitals group located in Paris region, France.
Methods: We reviewed the international classification of diseases 10 edition (ICD-10) discharge codes of the AP-HP hospitals group between 2011 and 2021.
Article Synopsis
- Prospective memory (remembering to do something in the future) and negative prospective memory (remembering not to do something) have been poorly understood in patients with Korsakoff's syndrome (KS).
- The study found that individuals with KS made more errors in both prospective and negative prospective memory tasks compared to control participants.
- The results suggest that KS patients struggle with both executing and inhibiting future intentions, likely due to difficulties in inhibiting previously learned behaviors.
Article Synopsis
- * This study aimed to develop a screening tool (ECAB) for identifying benzodiazepine use disorder in patients undergoing alcohol detoxification, where 15% of participants were found to have comorbid benzodiazepine use disorder.
- * Factors such as the type of prescriber and the presence of psychiatric disorders were linked to benzodiazepine use risks, highlighting that effective screening can aid in better management of these patients.
In this translational study, we investigated the plasma tau protein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCHL1), which are established biomarkers of neurological injury, as predictive biomarkers of alcohol withdrawal-associated brain toxicity. In the clinical study, patients with severe alcohol use disorder (AUD) on D1 of hospitalization for alcohol cessation (AC) (N = 36) were compared to severe AUD patients with at least 3 months of abstinence (N = 16). Overall, patients were 40 men (76.
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