While decreasing negative attitudes against outgroups are often reported by individuals themselves, biased behaviour prevails. This gap between words and actions may stem from unobtrusive mental processes that could be uncovered by using neuroimaging in addition to self-reports. In this study we investigated whether adding neuroimaging to a traditional intergroup bias measure could detect intersubject differences in intergroup bias processes in a societal context where opposing discrimination is normative.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) imposes a significant global health and economic burden, impacting millions globally. Despite its high prevalence, public awareness and understanding of CKD remain limited, leading to delayed diagnosis and suboptimal management. Traditional patient education methods, such as 1-on-1 verbal instruction or printed brochures, are often insufficient, especially considering the shortage of nursing staff.
View Article and Find Full Text PDFACS Chem Biol
January 2025
Multiple immune components in the complex and heterogeneous tumor-immune microenvironment (TIME) work cooperatively to promote or impede cancer immunotherapy. Synergistically co-managing multiple immune cells with single agents for advanced antitumor immunity remains desirable but challenging. This In Focus article introduces a triple orthogonal linker (T-Linker)-based multimodal targeting chimera (Multi-TAC) platform, enabling the single-agent-mediated tumor-targeted co-engagement of multiple immune cell types within TIME for potentiated immunotherapy.
View Article and Find Full Text PDFBackground: Astrocytes that become reactive in response to damage (e.g., due to typical brain aging or Alzheimer's Disease/AD pathologies) can have both adaptive (e.
View Article and Find Full Text PDFBackground: To maintain local dynamic stability (LDS), both cognitively and physically, without being interfered with by internal or external disturbance is important for functional independence but declines as ages. However, some older adults are capable of high dual-functional LDS. Understanding the brain differences between these older adults and their counterparts may help discover protective mechanisms for functional independence in old age.
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