Synthesis of Bodipy-Tagged Galactoconjugates and Evaluation of Their Antibacterial Properties.

As a development of our research on biocompatible glycoconjugate probes and specifically multi-chromophoric systems, herein, we report the synthesis and early bactericidal tests of two luminescent glycoconjugates whose basic structure is characterized by two boron dipyrromethene difluoride (BODIPY) moieties and three galactoside rings mounted on an oligophenylene ethynylene (OPE) skeleton. BODIPY fluorophores have found widespread application in many branches of biology in the last few decades. In particular, molecular platforms showing two different BODIPY groups have unique photophysical behavior useful in fluorescence imaging.

Photophysical Properties of Homo- and Hetero-Aggregate Assemblies Made of N-Annulated Perylene Derivatives.

We report the absorption spectra and photophysical properties of homo and hetero-aggregate assemblies of a strongly emissive N-annulated perylene dye (P) and of a dyad made of P and a methyl viologen derivative (P-MV), in ethanol-water solutions. In homo-aggregate assemblies of P, the π-π* fluorescence of the isolated chromophore is replaced by excimer emission at lower energy, with a lifetime of 900 ps, due to excimer formation from the initially prepared excitons. In homo-aggregate assemblies of P-MV, photoinduced charge separation, with formation of P -MV species, occurs in 3 ps with a charge recombination of 20 ps.

Photocatalyzed CO reduction to CO by supramolecular photocatalysts made of Ru(II) photosensitizers and Re(I) catalytic subunits containing preformed COTEOA adducts.

Two new supramolecular photocatalysts containing Ru(II) polypyridine units as light-harvesting photosensitizers and Re(I) polypyridine subunits as catalytic centers have been prepared. The new species, RuRe2A and Ru2ReA, contain catalytic Re(I) subunits coordinated by the preformed COTEOA adduct (known to be the effective catalytic subunits; TEOA is triethanolamine) and exhibit quite efficient and selective photoreduction of CO to CO, with outstanding TONs of 2368 and 2695 and a selectivity of 99.9% and 98.

Amino-OPE glycosides and blue light: a powerful synergy in photodynamic therapy.

Herein we report the synthesis and biological properties of sugar-conjugated oligophenylene ethynylene (OPE) dyes, used as novel photosensitizers (PSs) for photodynamic treatment (PDT) under blue light. The OPE-bearing glycosides at both ends are successfully prepared by a Pd-catalyzed Sonogashira cross-coupling reaction. The live-cell imaging studies have shown that these OPE glycosides (including glucose, mannose and maltose derivatives) efficiently penetrate the cytoplasm of cultured HeLa cancer cells.