Publications by authors named "F Prodam"
Aim: To assess the efficacy of the combined administration of myo-inositol and zinc, a mineral involved in the insulin pathway, in paediatric obesity with insulin resistance on HOMA-IR, glucose-insulin metabolism, and lipid profile.
Materials And Methods: Double-blind, randomized, placebo-controlled study conducted in North Italy. Fifty-six patients (10-18 years, Tanner stage ≥3) with obesity and insulin resistance were randomized to myo-inositol (2000 mg), zinc gluconate (5 mg), and galactooligosaccharides (GOS) from plant-based origin (1000 mg) (TRT) or placebo (PLC) containing only GOS from plant-based origin (1000 mg).
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through two neurohormones, the stimulating growth hormone releasing hormone (GHRH) and the inhibiting somatostatin. Shortly after its discovery and synthesis, GHRH was intensely investigated diagnostically to define GH secretion. The nascent enthusiasm for using GHRH as a single diagnostic tool to investigate GH deficiency (GHD) dropped down quickly due to a flawed reproducibility.
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- * Growth hormone deficiency (GHD) poses challenges due to varied diagnoses, daily treatment requirements, and lack of consistent biological markers, leading to a high potential for patient drop-out.
- * The review discusses GHD in transitioning patients, highlighting diagnostic difficulties, the importance of hormone replacement therapy, and the need for careful follow-up, especially in unique cases like cancer survivors.
Article Synopsis
- Pregnancy adds complexity to managing lipodystrophy disorders, which have been underreported in terms of related comorbidities and risks for women.
- A case study highlights a successful pregnancy in a 28-year-old woman with acquired partial lipodystrophy, showing improved glucose control but also leading to preterm delivery and maternal cardiac issues.
- Research indicates that while many women with various lipodystrophy phenotypes have successful pregnancies, they face high risks, necessitating intensive, multidisciplinary care and further investigation into leptin levels during pregnancy.
Objective: Decreased survival and higher cardiovascular morbidity have been recently reported in a UK cohort of 61 RTHβ patients, but there is no evidence from other countries.
Design: Retrospective cohort study from an historical group of 284 Italian RTHβ patients, diagnosed between 1984 and 2023.
Methods: We collected data on diagnosis of 284 cases and longitudinal data of 249 RTHβ who carried heterozygous pathogenic variants in the THRB gene.