Publications by authors named "F Pouthier"
Human amniotic membrane application in oral surgery-An pilot study.
Front Bioeng Biotechnol
October 2022
Article Synopsis
- - The study aimed to investigate the use of human amniotic membrane (hAM) as a graft material for treating medication-related osteonecrosis of the jaw (MRONJ) in a pig model, involving five oral and maxillofacial surgeons.
- - Four techniques for applying hAM were tested: complete coverage, partial coverage, apposition, and covering graft material, with surgeons assessing its handling and physical properties during the procedures.
- - Results indicated that hAM has suitable mechanical properties for oral surgery, with complete and partial coverage being the preferred techniques; findings are shared to educate surgeons on effective hAM application in surgical settings.
Article Synopsis
- MRONJ is a serious complication linked to treatments like bisphosphonates and lacks established management guidelines, especially in advanced cases.
- The human amniotic membrane (hAM) offers various healing benefits, such as low immunogenicity and properties that support tissue regeneration and reduce inflammation.
- In a study with eight cancer patients suffering from stage 2-3 MRONJ, using cryopreserved hAM resulted in significant healing improvements, pain relief, and no adverse events, with 80% showing healing at the six-month follow-up.
Chimeric Antigen Receptor (CAR) therapy has led to great successes in patients with leukemia and lymphoma. Umbilical Cord Blood (UCB), stored in UCB banks, is an attractive source of T cells for CAR-T production. We used a third generation CD123 CAR-T (CD28/4-1BB), which was previously developed using an adult's Peripheral Blood (PB), to test the ability of obtaining CD123 CAR-T from fresh or cryopreserved UCB.
View Article and Find Full Text PDFSurgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences.
Front Bioeng Biotechnol
June 2021
Due to its intrinsic properties, there has been growing interest in human amniotic membrane (hAM) in recent years particularly for the treatment of ocular surface disorders and for wound healing. Herein, we investigate the potential use of hAM and amnion-chorion membrane (ACM) in oral surgery. Based on our analysis of the literature, it appears that their applications are very poorly defined.
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