Publications by authors named "F Podmelle"
The local anesthetic lidocaine, which has been used extensively during liposuction, has been reported to have cytotoxic effects and therefore would be unsuitable for use in autologous lipotransfer. We evaluated the effect of lidocaine on the distribution, number, and viability of adipose-derived stem cells (ASCs), preadipocytes, mature adipocytes, and leukocytes in the fatty and fluid portion of the lipoaspirate using antibody staining and flow cytometry analyses. Adipose tissue was harvested from 11 female patients who underwent liposuction.
View Article and Find Full Text PDFArticle Synopsis
- Timely re-epithelialization is crucial in burn care to prevent complications like infections and scarring, highlighting the need for effective topical treatments to speed up healing.
- Preliminary studies suggest that betulin, derived from birch bark, can enhance wound healing for conditions such as second degree burns and skin graft donor sites.
- A phase III clinical trial with 219 participants showed that a topical betulin gel (TBG) significantly accelerated wound closure compared to standard treatment, with faster healing times and mild, manageable side effects.
Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing.
View Article and Find Full Text PDFThe aim of the study was to learn, whether clinical application of cold atmospheric pressure plasma (CAP) is able to cause (i) visible tumor surface effects and (ii) apoptotic cell kill in squamous cell carcinoma and (iii) whether CAP-induced visible tumor surface response occurs as often as CAP-induced apoptotic cell kill. Twelve patients with advanced head and neck cancer and infected ulcerations received locally CAP followed by palliative treatment. Four of them revealed tumor surface response appearing 2 weeks after intervention.
View Article and Find Full Text PDFArticle Synopsis
- * A controlled trial was conducted where one half of a wound received the ointment while the other served as a control; the results showed significant improvement in healing.
- * The trial was halted early due to the clear and significant benefits (p < 0.0001) of using Oleogel-S10, indicating it safely accelerates skin reepithelialization.