Publications by authors named "F Pociot"
Introduction: The identification of type 1 diabetes at an early presymptomatic stage has clinical benefits. These include a reduced risk of diabetic ketoacidosis (DKA) at the clinical manifestation of the disease and a significant reduction in clinical symptoms. The European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) represents a pioneering effort to advance early detection of type 1 diabetes through public health screening.
View Article and Find Full Text PDFBiological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an outcome of interest, for example, disease risk in a GWAS, at high levels of statistical significance, but with very small effects.
View Article and Find Full Text PDFAims/hypothesis: Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, shows some promise in alleviating beta cell stress and preserving beta cell function in preclinical studies of type 1 diabetes. The aim of this phase 2, placebo-controlled, double-blinded, randomised clinical trial was to investigate the efficacy and safety of fenofibrate in adults and adolescents with newly diagnosed type 1 diabetes.
Methods: We enrolled 58 individuals (aged 16 to 40 years old) with newly diagnosed type 1 diabetes and randomised them to daily oral treatment with fenofibrate 160 mg or placebo for 52 weeks (in a block design with a block size of 4, assigned in a 1:1 ratio).
Article Synopsis
- - The study aimed to assess the prevalence of diabetic polyneuropathy (DPN), cardiac autonomic neuropathy (CAN), and sudomotor dysfunction in children and adolescents with type 1 diabetes using simple bedside tests.
- - In a group of 221 participants with an average age of 14.2 years and diabetes duration of 4.8 years, findings showed that 40% had DPN, 17% had early CAN, and 5% experienced sudomotor dysfunction, with many having multiple types of neuropathy.
- - Despite good diabetes management and low complication rates, the research highlighted a significant presence of neuropathy and the importance of using various screening methods to detect these conditions accurately.