Publications by authors named "F Pivetti"
Article Synopsis
- The project aims to improve a previously studied MAPI compound for treating lung diseases by addressing its chemical stability and creating a balanced profile for bronchodilation and anti-inflammation in rats.
- Researchers tweaked the compound's chemical structure using insights from a unique crystal structure to enhance its efficacy without toxicity.
- The final identified compound was found to be chemically stable, potent, and safe for further development based on various tests in rats, indicating it could be effective in clinical settings.
Synthesis of C- and H-labelled CHF6001: A new potent PDE4 inhibitor.
J Labelled Comp Radiopharm
October 2017
An 8-step preparation of C-labelled CHF6001, a potent phosphodiesterase 4 inhibitor in the treatment of respiratory diseases, is described. An overall yield of approximately 9% was obtained starting from copper[ C]cyanide. The synthesis of a stable labelled version of CHF6001 is also reported using the commercially available trideuterated bromomethylcyclopropane as starting material.
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