Publications by authors named "F Pirini"
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC).
View Article and Find Full Text PDFBackground: Adjuvant trastuzumab is the standard of care for HER2+ breast cancer (BC) patients. However, >50% of patients become resistant. This study aimed at the identification of the molecular factors associated with disease relapse and their further investigation as therapeutically exploitable targets.
View Article and Find Full Text PDFDifferentially methylated regions (DMRs) can be used as head and neck squamous cell carcinoma (HNSCC) diagnostic, prognostic and therapeutic targets in precision medicine workflows. DNA from 21 HNSCC and 10 healthy oral tissue samples was hybridized to a genome-wide tiling array to identify DMRs in a discovery cohort. Downstream analyses identified differences in promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions associated with tumor differentiation, nodal involvement and survival.
View Article and Find Full Text PDFArticle Synopsis
- Follicular Lymphoma (FL) often leads to cycles of remission and relapse, making it nearly incurable, and current prognostic scores don't work well for all patients.
- This study analyzed 49 FL lymph node biopsies to explore the relationship between immune cell types in the tumor microenvironment and patient outcomes, focusing on specific markers like CD56 and CD163.
- Results indicated that certain ratios of immune cells were linked to survival rates, suggesting enhancing macrophage characterization could improve prognosis for FL patients, but further research is needed.
Article Synopsis
- PVs and LPVs in genes are linked to a higher risk of breast and ovarian cancers, especially in hereditary cases like HBOC; recent studies also connect these variants to pancreatic cancer.
- Inherited genetic factors account for 10% to 20% of pancreatic cancer cases, with variation in germline alterations among different ethnic groups, particularly in Italian HBOC families.
- The study focuses on a specific group of HBOC patients from the eastern coast of Emilia Romagna, aiming to determine the prevalence of a particular variant and its implications for cancer risk, which is important for genetic counseling and monitoring.