Publications by authors named "F Pinon"
Article Synopsis
- The hormone ghrelin plays a protective role in cancer-related anorexia-cachexia syndrome (CACS), with its levels rising to help combat weight loss and anorexia in cancer patients.
- A study found that deleting ghrelin worsened body weight and fat loss in mice with cancer, while deleting LEAP2, a ghrelin antagonist, seemed to lessen the severity of CACS.
- In human patients with CACS, a lower ratio of plasma LEAP2 to total ghrelin was associated with better weight stability, indicating a possible protective mechanism against worsening CACS.
Proton beam radiotherapy for uveal melanomas at nice teaching hospital: 16 years' experience.
Int J Radiat Oncol Biol Phys
September 2010
Purpose: To present the results of uveal melanomas treated at Nice Teaching Hospital.
Methods And Materials: This retrospective study included 886 consecutive patients referred to our clinic for the treatment of uveal melanomas by proton beam radiotherapy from June 1991 to December 2007. Survival rates were determined by using Kaplan-Meier estimates, and prognostic factors were evaluated using the log-rank test or Cox model.
Lipoatrophy is a rare cutaneous side-effect that can develop at the site of insulin injection. Since the introduction of human recombinant insulin the number of cases has decreased although cases have been reported in association with the use of rapid acting insulin analogues and continuous subcutaneous insulin infusion (CSII), recently one case has been reported with the use of insulin glargine. Insulin-induced lipoatrophy is a subcutaneous fat atrophy at the sites of injection which is relevant not only because of the cosmetic problem, but also because of the variability of absorption it causes in the site of injection.
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