Publications by authors named "F Pietrocola"
Article Synopsis
- ACBP/DBI is a protein linked to metabolic-associated steatohepatitis and liver fibrosis, showing higher levels in affected patients, correlating strongly with NAFLD and FIB4 scores, regardless of age or body mass index.
- A study used a monoclonal antibody to neutralize ACBP/DBI in various mouse models of liver disease, resulting in reduced signs of liver damage and halting disease progression.
- The results suggest ACBP/DBI plays a causal role in liver conditions and could be a potential therapeutic target for treating liver diseases.
Chronic kidney disease (CKD) is a strong risk factor for cardiovascular mortality and morbidity. We hypothesized that a senescent phenotype instigated by uremic toxins could account for early vascular aging (EVA) and vascular dysfunctions of microvasculature in end stage kidney disease (ESKD) patients which ultimately lead to increased cardiovascular complication. To test this hypothesis, we utilized both in vivo, and ex vivo approaches to study endothelial and smooth muscle function and structure, and characterized markers related to EVA in 82 ESKD patients (eGFR <15 ml/min) and 70 non-CKD controls.
View Article and Find Full Text PDFFibrosing interstitial lung diseases (ILDs) are characterized by the gradual and irreversible accumulation of scar tissue in the lung parenchyma. The role of the immune response in the pathogenesis of pulmonary fibrosis remains unclear. In recent years, substantial advancements have been made in our comprehension of the pathobiology driving fibrosing ILDs, particularly concerning various age-related cellular disturbances and immune mechanisms believed to contribute to an inadequate response to stress and increased susceptibility to lung fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Addressing immunological issues caused by aging is crucial for maintaining health, as the immune system is key in managing infections and helping tissue repair.
- Our study shows that using a flagellin-containing fusion protein to stimulate toll-like receptor 5 (TLR5) can improve the lifespan and overall health of mice, marked by less hair loss, better bone density, and improved cognitive function.
- This approach also strengthens gut health by enhancing TLR5 expression in specific immune cells and increasing the secretion of interleukin-22 (IL-22), indicating a promising way to promote healthy aging.