Publications by authors named "F Picconi"
Retinal neurodegeneration (RN), an early marker of diabetic retinopathy (DR), is closely associated with Müller glia cells (MGs) in diabetic subjects. MGs play a pivotal role in maintaining retinal homeostasis, integrity, and metabolic support and respond to diabetic stress. In lower vertebrates, MGs have a strong regenerative response and can completely repair the retina after injuries.
View Article and Find Full Text PDFBackground: This study aimed to analyze the potential pathogenic connection between metabolic factors, photoreceptor cell rearrangements, retinal microvascular perfusion, and functional parameters through multifocal electroretinography (mfERG) in type 1 diabetes mellitus (DM1).
Methods: This prospective observational cohort study enrolled DM1 patients (40.5 ± 9.
Purpose: To assess demographic, metabolic, and imaging predictors influencing microvasculature and photoreceptors changes over a 4-year follow-up in type 1 diabetes mellitus (DM1).
Methods: This prospective cohort study enrolled patients with DM1 with mild non-proliferative diabetic retinopathy. Complete medical records, glycosylated hemoglobin (HbA1c), optical coherence tomography angiography, and adaptive optics were collected for the 4 years of follow-up.
Purpose: To explore the potential relationships between macular vascular network and different adaptive optics (AO) metrics in patients with type 1 diabetes mellitus (DM1) with no signs (NoDR) or mild non-proliferative diabetic retinopathy (NPDR).
Design: Observational cross-sectional study.
Methods: Forty eyes of consecutive patients with DM1 (12 NoDR and 28 NPDR) and 10 healthy age-matched control subjects were included.
Article Synopsis
- * Using in vivo confocal microscopy, researchers developed a new algorithm to analyze beading size in the corneal sub-basal nerve plexus of T1DM patients compared to healthy controls.
- * Results showed that T1DM patients had significantly lower nerve fiber metrics but larger corneal beadings, suggesting alterations in nerve structure related to metabolic control in diabetes.