Publications by authors named "F Peyrin"
Article Synopsis
- The study focuses on the osteochondral interface, which includes calcified cartilage (CC) and subchondral bone (SCB), and presents a new method for analyzing chondrocyte and osteocyte lacunae in human knee samples using advanced imaging techniques.
- Researchers employed a combination of a marker-controlled watershed algorithm and deep learning (specifically nnU-Net) to enhance the 3D segmentation of cell lacunae, effectively improving the assessment of their structures.
- Findings showed that while chondrocyte characteristics didn't differ significantly between control and osteoarthritic knees, osteocytes in the osteoarthritic group exhibited lower anisotropy and tended to be more spherical,
Article Synopsis
- - Osteocytes play a crucial role in bone mechanobiology by communicating mechanical signals through the interconnected lacunocanalicular network (LCN) filled with interstitial fluid.
- - This study aimed to gather detailed morphological data on the human LCN using advanced imaging techniques, specifically measuring 27 femoral bone samples with a 100 nm voxel size.
- - Results showed variability in canalicular morphology, with some differences between males and females, although only larger canaliculi were detected; this research is groundbreaking as it presents new data for further investigations on LCN permeability.
Spectral photon-counting computed tomography (SPCCT) is a new technique with the capability to provide mono-energetic (monoE) images with high signal to noise ratio. We demonstrate the feasibility of SPCCT to characterize at the same time cartilage and subchondral bone cysts (SBCs) without contrast agent in osteoarthritis (OA). To achieve this goal, 10 human knee specimens (6 normal and 4 with OA) were imaged with a clinical prototype SPCCT.
View Article and Find Full Text PDFThe development of treatment strategies for skeletal diseases relies on the understanding of bone mechanical properties in relation to its structure at different length scales. At the microscale, indention techniques can be used to evaluate the elastic, plastic, and fracture behaviour of bone tissue. Here, we combined in situ high-resolution SRµCT indentation testing and digital volume correlation to elucidate the anisotropic crack propagation, deformation, and fracture of ovine cortical bone under Berkovich and spherical tips.
View Article and Find Full Text PDFLIDAR is an atmospheric sounding instrument based on the use of high-power lasers. The use of these lasers involves fulfilling obligations with respect to air safety. In this article, we present a low-cost air traffic surveillance solution integrated into an automated operating system for the Rayleigh-Mie-Raman LIDAR of Clermont Ferrand and the statistical elements of its application over more than two years of operation from September 2019 to March 2022.
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