Publications by authors named "F Perez Azorin"
Chromatin-associated RNAs (cRNAs) are a poorly characterized fraction of cellular RNAs that co-purify with chromatin. Their full complexity and the mechanisms regulating their packaging and chromatin association remain poorly understood. Here, we address these questions in Drosophila.
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- Chromosome pairing is crucial for genome organization, but the mechanisms in somatic cells, particularly in Drosophila, are not well understood, despite their pronounced pairing features.
- The study identifies two factors that influence the localization of CAP-H2, an anti-pairing protein, particularly focusing on Z4's role in its function at architectural protein binding sites (APBSs).
- Additionally, they discover that osmotic stress can cause rapid unpairing of chromosomes, emphasizing the relationship between chromosome pairing and different types of 3D interactions within the genome.
In the nucleus, chromatin is intricately structured into multiple layers of 3D organization important for genome activity. How distinct layers influence each other is not well understood. In particular, the contribution of chromosome pairing to 3D chromatin organization has been largely neglected.
View Article and Find Full Text PDFPost-translational modifications (PTMs) of core histones are important epigenetic determinants that correlate with functional chromatin states. However, despite multiple linker histone H1s PTMs have been identified, little is known about their genomic distribution and contribution to the epigenetic regulation of chromatin. Here, we address this question in Drosophila that encodes a single somatic linker histone, dH1.
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- Scientists studied genes on the X chromosome to understand their role in male fertility, especially for men with low or no sperm production.
- They found 21 new important genes and 34 that are somewhat important for these conditions, including one gene called RBBP7 that was often mutated.
- This research helps fill gaps in understanding genetic reasons for male infertility and could lead to better tests in the future.