Publications by authors named "F Perbellini"
Article Synopsis
- Heart failure (HF) is a rising global health issue often related to cardiac injury, linked to high mortality rates and insufficient treatment options; ferroptosis, an iron-dependent cell death, may play a significant role in heart disease.
- This study aimed to create an ex-vivo model using living myocardial slices (LMS) to explore mechanisms and identify potential drug targets related to myocardial injury.
- Results showed that cryoinjured rat LMS exhibited symptoms like contractile dysfunction and inflammation, with ferroptosis playing a notable role; treatment with ferrostatin (Fer-1) improved cardiac function and reduced damage, indicating a promising therapeutic avenue.
Article Synopsis
- Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show potential as a treatment for heart attacks, but they often cause temporary irregular heartbeats known as engraftment arrhythmias (EAs).
- Researchers believe these EAs are due to the immature nature of hPSC-CMs, as they exhibit pacemaker-like activity influenced by specific ion channels.
- By modifying the ion channels in these stem cells to reduce automaticity, the study demonstrated that these engineered cells can be safely transplanted into pig hearts without causing sustained EAs, supporting the idea that improving the electrophysiological properties of hPSC-CMs could enhance their use in heart therapies.
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the heart. Plasticity and activation are hallmarks of rcMACs in response to changes in the microenvironment, which is essential for in vitro experimentation. The in vivo investigation is confounded by the infiltration of other cells hindering direct studies of rcMACs.
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