Publications by authors named "F Panagopoulos"
Kidney disease is linked to the development of cardiovascular disorders, further increasing morbidity and mortality in this high-risk population. Thus, early detection of myocardial damage is imperative in order to prevent devastating cardiovascular complications within this patient group. Over the years, cardiac biomarkers have been identified and are now widely used in everyday clinical practice.
View Article and Find Full Text PDFBackground: Macrophage migration inhibitory factor (MIF) is a highly conserved cytokine with pleiotropic properties, mainly pro-inflammatory. MIF seems to exert its pro-inflammatory features by binding to its transmembrane cellular receptor CD74. MIF also has CXCR4, which acts as a co-receptor in this inflammatory process.
View Article and Find Full Text PDFThe lactate to albumin ratio (LAR) has been associated with the severity and outcome of critical illness and sepsis. However, there are no studies on the kinetics of the LAR during the early phase of sepsis. Therefore, we aimed to investigate the LAR and its kinetics in critically ill patients with new onset sepsis regarding the severity and outcome of sepsis.
View Article and Find Full Text PDFArticle Synopsis
- * Scoliosis in OI patients is characterized by various vertebral deformities like wedged vertebrae and abnormalities at the craniocervical junction, and its progression is linked to reduced Bone Mineral Density and multiple contributing factors such as mechanical strain and bone metabolism anomalies.
- * Investigating the molecular mechanisms, particularly the role of Transforming Growth Factor-β (TGFβ) signaling, offers potential insights for new therapeutic strategies targeting the bone and muscle challenges faced by OI patients.
Current Progress and Future Perspectives in Contact and Releasing-Type Antimicrobial Coatings of Orthopaedic Implants: A Systematic Review Analysis Emanated from In Vitro and In Vivo Models.
Infect Dis Rep
March 2024
Article Synopsis
- The prevalence of postoperative implant-related infections remains a significant concern, despite advanced orthopedic devices and strict protocols.
- A systematic review analyzed 31 in vitro and 40 in vivo studies on antimicrobial, silver, and iodine-coated implants, highlighting their potential effectiveness against infections.
- Results showed that specially coated implants demonstrated broad antimicrobial capabilities, reduced bacterial growth, and improved osseointegration, suggesting that surface modifications could be a viable solution to combat infections in clinical orthopedic settings.