Publications by authors named "F Pack"
The potential of standard methods of radiation therapy is limited by the dose that can be safely delivered to the tumor, which could be too low for radical treatment. The dose efficiency can be increased by using radiosensitizers. In this study, we evaluated the sensitizing potential of biocompatible iron oxide nanoparticles coated with a dextran shell in A172 and Gl-Tr glioblastoma cells in vitro.
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- Proton boron capture therapy (PBCT) aims to improve proton therapy's effectiveness by utilizing proton-boron fusion reactions that theoretically increase dose delivery in cancer cells.
- The study investigated the effectiveness of sodium borocaptate (BSH) in enhancing proton radiation's effects on glioma cells, showing only minimal improvement in cell viability and colony formation after treatment.
- Findings suggest that the anticipated benefits of PBCT may not materialize due to the complicated interactions within irradiated tissues, indicating a need for further research into secondary effects rather than just direct dose enhancements.
Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults.
Hypertension
March 2021
It is unknown whether obesity modifies the effect of obstructive sleep apnea (OSA) and positive airway pressure (PAP) therapy on cardiac remodeling and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. We compared NT-proBNP and cardiac magnetic resonance imaging in adults without OSA (n=56) and nonobese (n=73; body mass index <30 kg/m) and obese (n=136; body mass index ≥30 kg/m) adults with OSA. We also investigated these traits in nonobese (n=45) and obese (n=78) participants with OSA adherent to 4 months of PAP treatment.
View Article and Find Full Text PDFStudy Objectives: Sleep spindles, a defining feature of stage N2 sleep, are maximal at central electrodes and are found in the frequency range of the electroencephalogram (EEG) (sigma 11-16 Hz) that is known to be heritable. However, relatively little is known about the heritability of spindles. Two recent studies investigating the heritability of spindles reported moderate heritability, but with conflicting results depending on scalp location and spindle type.
View Article and Find Full Text PDFBackground: Extreme phenotypes of OSA have not been systematically defined.
Research Question: This study developed objective definitions of extreme phenotypes of OSA by using a multivariate approach. The utility of these definitions for identifying characteristics that confer predisposition toward or protection against OSA is shown in a new prospective sample.