Publications by authors named "F Pacchierotti"
Effects of radiofrequency electromagnetic field (RF-EMF) exposure on male fertility: A systematic review of experimental studies on non-human mammals and human sperm in vitro.
Environ Int
March 2024
Background: The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Reproductive health outcomes have been identified among the priority topics to be addressed.
Objectives: To evaluate the effect of RF-EMF exposure on male fertility of experimental mammals and on human sperm exposed in vitro.
Background: The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Within the project, 6 topics have been prioritized by an expert group, which include reproductive health outcomes.
Objectives: According to the protocol published in 2021, a systematic review and meta-analyses on the adverse effects of RF-EMF exposure during pregnancy in offspring of experimental animals were conducted.
The ethanolic extract of hazelnut, prepared in our laboratories, has been previously characterized by liquid chromatography coupled to high resolution mass spectrometry. We here aimed at testing the antioxidant effect of such extract in HO-challenged THLE-2 human primary hepatocytes and verified whether it might be based on microRNA-34b/c expression changes. We here demonstrate that miR-34b/miR-34c undergo significant stimulation (≥2-fold change, < 0.
View Article and Find Full Text PDFPyrogenic synthetic amorphous silica (NM-203): Genotoxicity in rats following sub-chronic oral exposure.
Mutat Res Genet Toxicol Environ Mutagen
May 2022
Article Synopsis
- - A study examined the potential genotoxic effects of nano-structured synthetic amorphous silica (SAS), a common food additive, by conducting a 90-day oral toxicity test on adult rats, using doses that simulate potential human exposure.
- - Various tests, including the comet assay, Pig-a assay, and micronucleus assay, were performed on different organs to evaluate DNA damage and mutations.
- - Results showed no significant increases in gene mutations or chromosome damage in blood or colon, but there was a weak genotoxic effect observed in the spleen.
Background: Radiofrequency Electromagnetic Fields (RF-EMF) at environmental level have been reported to induce adverse effects on the male reproductive system and developing embryos. However, despite the number of experiments conducted since the 1970s, the diversity of testing approaches and exposure conditions, inconsistencies among results, and dosimetric flaws have not yet permitted a solid assessment of the relationship between RF-EMF exposure and such effects, warranting a more systematic and methodologically rigorous approach to the evaluation of available data.
Objectives: This study aims at evaluating the effects of RF-EMF exposure on male fertility and pregnancy outcomes by a systematic review (SR) of experimental studies, conducted in compliance with international guidelines.