Publications by authors named "F P Selvaggi"
Article Synopsis
- Obesity can lead to serious health problems, including memory loss and dementia, because it changes how our brain and body work.
- When someone is obese, it can cause inflammation and other problems in the brain that make it harder for brain cells to stay healthy.
- This information helps scientists find ways to prevent brain issues related to obesity, looking at both medicine and lifestyle changes that might help.
Article Synopsis
- - The study investigates the occurrence of metachronous colorectal cancer in patients diagnosed with early-onset colorectal cancer (under 50 years old), finding an overall incidence of 2.6%.
- - It highlights that patients with Lynch syndrome have a significantly higher incidence of metachronous colorectal cancer at 18.43%, while those with a family history have a rate of 10.52%.
- - The findings suggest that although early-onset colorectal cancer patients have a similar risk as older patients, specific genetic and familial factors significantly increase their risk, indicating the need for personalized management strategies.
In the tumor microenvironment (TME), ROS production affects survival, progression, and therapy resistance in colorectal cancer (CRC). HO-mediated oxidative stress can modulate Wnt/β-catenin signaling and metabolic reprogramming of the TME. Currently, it is unclear how mild/moderate oxidative stress (eustress) modulates Wnt/β-catenin/APC and JNK signaling relationships in primary and metastatic CRC cells.
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- Anal fissure is a common condition involving a tear in the anal tissue, leading to pain and bleeding during bowel movements.
- Chronic anal fissures can severely affect a person's quality of life, requiring various treatment options.
- This article reviews the historical development of our understanding and treatment of anal fissures, marking significant milestones from ancient times to today.
Treatment of rectal cancer has improved over the years thanks to a multidisciplinary approach. A correct staging has a fundamental role for risk stratification and to define the best treatment for each patient. Unfortunately, approximately 30% of patients with locally advanced rectal cancers will experience tumor recurrence.
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