Publications by authors named "F P Noonan"
Background: Dizziness and vertigo are common referrals to Ear Nose Throat (ENT) outpatient services however these services have long waitlists for assessment. Primary contact physiotherapy-led vestibular clinics are recognized as improving access to care. This pilot study investigated agreement between physiotherapists and an ENT medical practitioner for diagnostic and management decisions in patients attending a primary contact physiotherapy-led vestibular clinic.
View Article and Find Full Text PDFHepatocyte growth factor-overexpressing mice that harbor a deletion of the Ink4a/p16 locus (HP mice) form melanomas with low metastatic potential in response to UV irradiation. Here we report that these tumors become highly metastatic following hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice). Whole-genome sequencing of melanomas from HPN mice revealed a striking increase in lung metastatic activity that is associated with missense mutations in eight signature genes (Arhgap35, Atp8b4, Brca1, Ift172, Kif21b, Nckap5, Pcdha2, and Zfp869).
View Article and Find Full Text PDFArticle Synopsis
- NME1 is a metastasis-suppressor gene that inhibits metastatic activity in various cancers without altering their growth.
- Research involved removing Nme1 and Nme2 genes in a mouse model of UVR-induced melanoma to evaluate their roles.
- The results showed increased metastatic activity in both male and female mice lacking these genes, with a notable increase in females, highlighting Nme2's role as a metastasis-suppressor for the first time in this context.
Objectives: Intracapsular tonsillectomy (tonsillotomy) has been used internationally, mainly in the management of obstructive sleep apnoea, rather than recurrent tonsillitis, with few published data evaluating its use for this latter indication. We present long-term prospective data from 500 paediatric cases undergoing Coblation intracapsular tonsillectomy, for both obstructive and infective indications.
Design: Prospective case series, March 2013-January 2016, all with completed follow-up.