Publications by authors named "F P Monroy"
Evidence of discrete acoustic Rayleigh wave turbulence (DARWT) is reported on the free surface of complex viscoelastic materials under monochromatic excitation. These surface elastic non-linear Rayleigh waves exhibit dispersionless dynamics governed by bulk shear rigidity at coexistence with dispersive capillary waves supported by surface tension. Using Laser Doppler Vibrometry (LDV), the discrete Kolmogorov-Zakharov (KZ) spectrum is measured, characterized by a power-law envelope in an inertial cascade of discrete harmonics.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a 12% survival rate, highlighting the need for novel therapies. c-MYC overexpression, driven by upstream mutations and amplifications, reprograms tumor metabolism and promotes proliferation, migration and metastasis. This study identifies ELOVL6, a fatty acid elongase regulated by c-MYC, as a potential therapeutic target.
View Article and Find Full Text PDFIntroduction: The treatment for patients with high-grade gliomas includes surgical resection of tumor, radiotherapy, and temozolomide chemotherapy. However, some patients do not respond to temozolomide due to a methylation reversal mechanism by the enzyme O-methylguanine-DNA-methyltransferase (MGMT). In patients receiving treatment with temozolomide, this biomarker has been used as a prognostic factor.
View Article and Find Full Text PDFArticle Synopsis
- The study introduces a neo-Hookean elasticity theory for hybrid mechano-active hydrogels by incorporating motor proteins into polymer structures, leading to materials that actively soften due to adjustable chain overlaps.
- The focus is on polyacrylamide hydrogels enhanced with the bacterial protein FtsZ, using a multiscale model that combines microscopic rubber mesh theory, mesoscopic scaling concepts, and phase transition formalism to explain the observed active softening.
- This research provides valuable insights for designing and controlling complex active hydrogels, potentially advancing applications in technology and biomedicine.
Background/objectives: Leptospirosis is a zoonotic disease that is widely distributed around the world and presents symptoms similar to other febrile illnesses in tropical regions, which complicates clinical diagnosis. This study aimed to evaluate the performance and agreement between serological diagnostic tests for detecting both acute and convalescent human leptospirosis, using the micro agglutination test (MAT) as a reference in an endemic region of the Colombian Caribbean.
Methods: A prospective descriptive study was conducted on 275 participants with suspected leptospirosis.