Publications by authors named "F P McGrath"
Ultrashort pulses can excite or ionize molecules and populate coherent electronic wave packets, inducing complex dynamics. In this Letter, we simulate the coupled electron-nuclear dynamics upon ionization to different electronic wave packets of (deuterated) benzene and fluoro-benzene molecules, quantum mechanically and in full dimensionality. In fluoro-benzene, the calculations unravel both interstate and intrastate quantum interferences that leave clear signatures of attochemistry and charge-directed dynamics in the shape of the autocorrelation function.
View Article and Find Full Text PDFSars-CoV2/COVID-19 pandemic created a national emergency in Ireland. Our institution implemented a virtual trauma assessment clinic to reduce attendance to our district hospital which was stimulated by the development of 'safe-distanced' care. The audit aimed to evaluate the impact of our trauma assessment clinic on care provision and presentation to hospital.
View Article and Find Full Text PDFArticle Synopsis
- Researchers aimed to improve understanding of anaphylaxis by examining changes in gene expression in patients presenting with varying severities of the condition.
- An analysis of a microarray data set revealed that severe anaphylaxis showed dysregulated platelet aggregation at initial presentation, a phenomenon not seen in moderate cases or other conditions like sepsis or trauma.
- Seven specific genes related to platelet function were significantly downregulated in severe anaphylaxis patients who hadn't received adrenaline, suggesting that these genetic changes could indicate the severity of the anaphylactic reaction.
Article Synopsis
- Somatic mutations play a crucial role in cancer development, with many known driver mutations found in protein coding regions, but the impact of mutations in miRNAs and their binding sites is poorly understood.
- This study created cancer-specific miRNA regulatory networks for 30 cancer types, analyzing over 3.5 million mutations and revealing that mutations in miRNAs often occur alongside mutations in their target genes, influencing gene expression.
- The findings highlight 148 potential driver mutations that disrupt miRNA networks, suggesting that downregulated targets in 3' UTRs may act as tumor suppressors, and they introduce a web portal (mGI-map) to help researchers explore this data for future biomarker and drug development.
A woman in her 40s with advanced bladder cancer was admitted to hospital with hypercalcaemia of malignancy. Initially, she presented with non-specific symptoms of malaise, fatigue and general deterioration. She was treated with intravenous fluids and zoledronic acid in order to bring her calcium levels down, but subsequently developed significant hypocalcaemia.
View Article and Find Full Text PDF