Publications by authors named "F P Kirkels"
Aim: The identification of myocardial scar is key in clinical decision-making after acute myocardial infarction (AMI). However, the gold standard that is cardiac magnetic resonance imaging (CMR) encounters limitations in terms of availability. Two-dimensional speckle tracking echocardiography (2D-STE) may be an accessible alternative in detecting scar and assessing scar transmurality.
View Article and Find Full Text PDFBackground: Integration of a patient's non-invasive imaging data in a digital twin (DT) of the heart can provide valuable insight into the myocardial disease substrates underlying left ventricular (LV) mechanical discoordination. However, when generating a DT, model parameters should be identifiable to obtain robust parameter estimations. In this study, we used the CircAdapt model of the human heart and circulation to find a subset of parameters which were identifiable from LV cavity volume and regional strain measurements of patients with different substrates of left bundle branch block (LBBB) and myocardial infarction (MI).
View Article and Find Full Text PDFArticle Synopsis
- Arrhythmic mitral valve prolapse (AMVP) is a serious heart condition that can cause dangerous heart rhythms, especially in young women.
- Researchers looked at women with AMVP who had troubling heart rhythms during and after pregnancy to see if being pregnant raised their risk.
- They found that these women had more dangerous heart rhythms during pregnancy and up to 6 months after giving birth compared to when they weren't pregnant.
Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?
Eur Heart J Cardiovasc Imaging
May 2024
Aims: Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort.
Methods And Results: This retrospective multi-centre study included 185 IVF patients [median age 39 (27, 52) years, 40% female].
Article Synopsis
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) leads to dangerous heart rhythms due to fibrofatty heart tissue replacement, making early detection vital for at-risk relatives.
- This study examined whether screening protocols for ARVC should be adjusted by age, analyzing patients grouped by their ages (<30, 30-50, and ≥50 years) over an average follow-up of 6.7 years.
- Results indicated no significant differences in disease progression across age groups, highlighting that older patients (over 50) could also experience serious complications despite lacking clear ARVC symptoms at the start.