Does an early post traumatic knee brace reduce the incidence of knee rotational instability?

Purpose: Several anterolateral stabilization procedures have been developed recently to address rotational instability of the knee. Currently, these procedures tend to be systematically used by some practitioners. However, antero-lateral structures of the knee (including the anterolateral ligament, ALL) have a self-healing potential which can reduce the need to perform an antero-lateral procedure.

Clinical evaluation of a resurfacing device implant for femoral osteochondral defects greater than 1 cm with a minimal follow-up of 4 years: a prospective cohort study.

Purpose: Osteochondral defects have a limited capacity to heal and can evolve to an early osteoarthritis. A surgical possibility is the replacement of the affected cartilaginous area with a resurfacing device BioPoly™ RS Partial Resurfacing Knee Implant. The aim of this study was to report the clinical and survival outcomes of the BioPoly™ after a minimum follow-up of 4 years.

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level.

The extracellular matrix (ECM) of articular cartilage is a three-dimensional network mainly constituted of entangled collagen fibrils and interfibrillar aggrecan aggregates. During the development of osteoarthritis (OA), the most common musculoskeletal disorder, the ECM is subjected to a combination of chemical and structural changes that play a pivotal role in the initiation and the progress of the disease. While the molecular mechanisms involved in the pathological remodelling of the ECM are considered as decisive, they remain, however, not completely elucidated.

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.

Introduction: Osteoarthritis (OA) is a whole-joint disease characterized by a low-grade inflammation that is involved in both cartilage degradation and subchondral bone remodeling. Since subchondral bone has a cholinergic innervation and that acetylcholine (Ach) might have an anti-inflammatory effect through the α7 nicotinic Ach receptor (α7nAchR), we aimed (i) to determine the expression of non-neuronal cholinergic system and nicotinic receptor subunits by murine and human osteoblasts, (ii) to address the role of α7nAchR in osteoblastic response to inflammation, and (iii) to study the role of α7nAchR in a spontaneous aging OA model.

Methods: Primary cultures of WT and α7nAchR knock-out mice (Chrna7) murine osteoblasts and of subchondral bone human OA osteoblasts were performed.

A 180° Spin of the Femoral Component in Unicompartmental Knee Arthroplasty: A Report of 2 Cases.

Case: We report 2 cases of undescribed lateral unicompartmental knee arthroplasty failure: a 180° rotation of the femoral component. The patients experienced a locking event several years after arthroplasty, and radiographs revealed a perfect 180° rotation of the implant. Each patient underwent revision surgery to a total knee arthroplasty.