Publications by authors named "F P Edenborough"
Article Synopsis
- - A patient with cystic fibrosis was treated with linezolid for a lung infection but developed severe lactic acidosis, leading to issues with blood clotting and low blood cell counts.
- - The lactic acidosis didn't respond to standard treatment but improved within 20 hours after starting a specific type of kidney support called continuous veno-venous haemofiltration.
- - However, the haemofiltration made it harder to perform chest physiotherapy, which worsened the patient's lung problems and extended their need for antibiotic treatment; this highlights the importance of monitoring lactate levels in patients on linezolid.
The introduction of Cystic Fibrosis Trans Regulatory modulator (CFTRm) drugs has seen a transformation in Cystic Fibrosis (CF) treatment. This has led to a significant improvement in lung function and quality of life with the potential for a real impact on life expectancy. Transient mild to moderate hepatic transaminitis is a well-known side effect of CFTRm drugs, which often improves on cessation and may not recur following the re-institution of the drug.
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- - Daily inhaled therapy is crucial for maintaining lung health in people with cystic fibrosis (PwCF), but measuring adherence to therapy can be complicated due to varying treatment regimens among patients.
- - This study utilizes historical data from the UK CF Registry (2011-2015) to create a prediction rule for identifying current Psuedomonas aeruginosa (PA) status in PwCF, achieving high accuracy rates in predictions.
- - By effectively identifying patients with chronic PA infection using past registry data, the researchers aim to improve adherence monitoring and quality assessments of care across different medical centers.