Publications by authors named "F P Busardo"
Background: Isotopologues resulting from the labelling of molecules with deuterium have attracted interest due to the isotope effect observed in chemistry and biosciences. Isotope effect may also play out in noncovalent interactions and mechanisms leading to intermolecular recognition. In chromatography, differences in retention time between isotopologues, as well as between isotopomers have been observed resulting in two different elution sequences (isotope effects): the normal isotope effect when heavier isotopologues retain longer than lighter analogues, and the inverse isotope effect featuring the opposite elution order.
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- The synthesis and illegal use of designer benzodiazepines are increasing concerns, causing serious health risks and challenges for toxicologists in identifying and confirming their use.
- The review analyzes the metabolism of various classes of benzodiazepines, highlighting key biomarkers for human consumption that are essential in toxicology.
- A systematic literature search uncovered 30 studies on designer benzodiazepines' metabolism from 2007 to 2023, revealing prevalent metabolites and emphasizing the need for further research to address gaps in understanding these substances.
Background: The abuse of psychoactive substances presents challenges in clinical and forensic toxicology. The emergence of novel and potent drugs that pose significant health risks, in particular towards frequent abusers and users unaware of the ingredients, further complicates the situation. Designer benzodiazepines have become a fast-growing subgroup of these new psychoactive substances (NPSs), and their overdose may potentially turn fatal, especially when combined with other central nervous system depressants.
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- Radical surgery is the most effective treatment for early-stage lung cancer, with video-assisted thoracic surgery (VATS) being a less painful alternative to traditional surgery methods.
- Current localization techniques for identifying lung cancer are limited, particularly the near-infrared (NIR) indocyanine green (ICG) method, which struggles with deep tissue and lymph node detection.
- This study tests the effectiveness of Cetuximab-IRDye800CW, a combination of a monoclonal antibody and an advanced NIR dye, in accurately marking lung nodules and lymph nodes during VATS for improved detection outcomes.
Recently, hexahydrocannabinol (HHC) was posed under strict control in Europe due to the increasing HHC-containing material seizures. The lack of analytical methods in clinical laboratories to detect HHC and its metabolites in biological matrices may result in related intoxication underreporting. We developed and validated a comprehensive GC-MS/MS method to quantify 9(R)-HHC, 9(S)-HHC, 9αOH-HHC, 9βOH-HHC, 8(R)OH-9(R)-HHC, 8(S)OH-9(S)HHC, 11OH-9(R)HHC, 11OH-9(S)HHC, 11nor-carboxy-9(R)-HHC, and 11nor-carboxy-9(S)-HHC in whole blood, urine, and oral fluid.
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