Effects of immune modulatory treatment on language and psychiatric profile in patients with electrical status epilepticus in sleep (ESES).

Electrical status epilepticus in sleep (ESES) is an electrographic pattern associated with cognitive impairment. Our study aimed to prospectively evaluate the psychiatric findings and language skills in patients diagnosed with ESES and to determine the immune modulatory treatment-responsive subgroups. We assessed the patients for psychiatric features and language skills at the baseline and 12 months after.

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.

Harnessing Extrinsic Dissipation to Enhance the Toughness of Composites and Composite Joints: A State-of-the-Art Review of Recent Advances.

Interfaces play a critical role in modern structures, where integrating multiple materials and components is essential to achieve specific functions. Enhancing the mechanical performance of these interfaces, particularly their resistance to delamination, is essential to enable extremely lightweight designs and improve energy efficiency. Improving toughness (or increasing energy dissipation during delamination) has traditionally involved modifying materials to navigate the well-known strength-toughness trade-off.

Assessing the efficacy of pearl millet and finger millet enriched breakfast cereals to combat obesity.

This research explores the development and evaluation of breakfast cereals formulated from pearl millet (P-1) and finger millet (F-1) flours, with a focus on their nutritional composition and potential anti-obesity properties. The techno-functional properties were assessed, revealing that P-1 exhibited a bulk density of 0.40 ± 0.

Controlled release and biological properties of prochitosomes loaded with Arthrospira derived peptides: Membrane stability, chemical, morphological and structural monitoring.

In this study, the effects of chitosan-coating on maintaining the integrity and stability of the membrane, structural, and morphological changes, and the release of loaded peptides inside nanoliposomes during various in vitro release, thermal, freeze-thaw, shear, and dehydration (spray-drying) tensions were evaluated. Among different peptidic fractions (100, 30, and 10 kDa), the Arthrospira derived PF-30 kDa showed a higher nutritional and biological value. PF-30kDa was loaded successfully (EE ~ 90 %) inside nanoliposomes (NLs) and its stabilization was done with chitosan coating (0.