Publications by authors named "F Oyen"
Article Synopsis
- Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a diverse and challenging type of cancer that often has poor outcomes, especially in younger patients lacking the SMARCB1 protein.
- Research indicated that human and mouse PTCL-NOS exhibit similar DNA changes, including the hypermethylation of T-cell genes and the hypomethylation of myeloid development genes, contributing to a complicated tumor ecosystem.
- A study found that histone deacetylase inhibitors (HDACi), like SAHA, can effectively treat PTCL-NOS by modifying the tumor's microenvironment and improving immune function, paving the way for potential combination therapies.
Article Synopsis
- Malignant rhabdoid tumors mainly affect young children and are linked to genetic changes in the SMARCB1 gene; about 30% of patients have one altered SMARCB1 allele, leading to poorer outcomes.
- A study of 29 patients with sporadic rhabdoid tumors investigated the frequency and impact of constitutional mosaicism (having mutated genes in some but not all cells) using advanced DNA sequencing techniques.
- The research found constitutional mosaicism in 21% of patients, suggesting it is common in these tumors; however, there were no significant differences in clinical outcomes between patients with and without mosaicism, indicating more research is necessary.
Reporter genes are important tools in many biological disciplines. The discovery of novel reporter genes is relatively rare. However, known reporter genes are constantly applied to novel applications.
View Article and Find Full Text PDFBackground: Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS tumors of infancy and early childhood. Hallmark is the surprisingly simple genome with inactivating mutations or deletions in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T cells.
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