Publications by authors named "F Obata"
Introduction: Acute encephalopathy (AE) in childhood due to a viral infection causes convulsions and altered consciousness, leading to severe sequelae and death. Among the four types of AE, cytokine storm-induced AE is the most severe and causes serious damage to the brain. Moreover, a fundamental treatment for AE has not been established yet.
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- PET imaging using Zr is gaining traction for visualizing immune and cancer cells, but has limitations due to low image quality from gamma ray emissions.
- A new prototype has been developed to improve Compton imaging within PET by redesigning the scatter detector and optimizing image reconstruction methods.
- The upgraded WGI system showed enhanced imaging performance, including improved angular resolution, sensitivity, and reduced noise, demonstrating successful in-vivo imaging of a mouse with tumor burden after Zr labeled antibody injection.
An excessive immune response damages organs, yet its molecular mechanism is incompletely understood. Here, we screened a factor mediating organ damage upon genetic activation of the innate immune pathway using Drosophila renal tubules. We found that an antimicrobial peptide, Attacin-D (AttD), causes organ damage upon immune deficiency (Imd) pathway activation in the Malpighian tubules.
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- Initial studies showed that SARS-CoV-2 spike protein vaccines had sub-optimal effectiveness in mammals, leading researchers to explore improvements through protein engineering and adjuvants.
- The comparison of engineered protein vaccines and protein-nanoparticle vaccines was rare, prompting experiments where mice and hamsters were vaccinated with sequence-optimized spike proteins and nanoparticles.
- Results indicated that the immune response and protection from the virus were similar for both spike-only and spike-nanoparticle vaccines, suggesting that optimized protein subunit vaccines in trimer form can be just as effective as scaffolded versions.
Dietary protein intake modulates growth, reproduction, and longevity by stimulating amino acid (AA)-sensing pathways. Essential AAs are often considered as limiting nutrients during protein scarcity, and the role of dietary non-essential AAs (NEAAs) is less explored. Although tyrosine has been reported to be crucial for sensing protein restriction in larvae, its effect on adult physiology and longevity remains unclear.
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