Publications by authors named "F OEzlem Orhan"
Article Synopsis
- STAT3 gain-of-function disease causes issues like immune system overactivity and growth problems, but long-term treatment with the JAK inhibitor ruxolitinib has shown promise in symptom relief.
- The study monitored clinical and immune responses of four patients over a year, noting significant changes in T cell populations and the normalization of blood cell profiles, which were previously dysregulated.
- Ruxolitinib treatment not only managed symptoms but also modified harmful immune cell characteristics and reduced certain auto-reactive T-cell clones, suggesting a potential pathway to better control the disease's impact.
Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 2019 (COVID-19). Metabolites of the kynurenine pathway have been proposed to account for cognitive impairment in COVID-19 patients. Here, cerebrospinal fluid (CSF) and plasma levels of kynurenine pathway metabolites in 53 COVID-19 patients and 12 non-inflammatory neurological disease controls in Sweden were measured with an ultra-performance liquid chromatography-tandem mass spectrometry system (UPLC-MS/MS) and correlated with immunological markers and neurological markers.
View Article and Find Full Text PDFBackground: Diagnosing anaphylaxis in children within the first 2 years of life can be difficult due to the often confusing and nonspecific signs and symptoms.
Objective: This study focuses on the phenotype of anaphylaxis in children within the first 2 years of life and aims to increase awareness of anaphylaxis in this age group.
Methods: The study included children between 0 and 2 years who were diagnosed as having anaphylaxis by pediatric allergists in 11 tertiary hospitals.
Article Synopsis
- IPEX is a rare autoimmune disorder caused by FOXP3 variants, presenting diverse symptoms like early-onset diabetes, eczema, and enteropathy, creating challenges in diagnosis and management.
- A study of 12 IPEX patients analyzed clinical features and immunological characteristics, revealing a distinction between classical and atypical cases, with atypical patients showing more allergic symptoms and severe chronic diarrhea.
- Most patients were treated with immunosuppressants or underwent hematopoietic stem cell transplantation, with HSCT showing the most effective long-term control of symptoms, and sirolimus providing better outcomes than other immunosuppressants.
Sugar beet molasses: a sweet solution for ectoine production by Nesterenkonia sp.
Environ Sci Pollut Res Int
August 2024
Ectoine, a biologically significant compound, was successfully produced by a strain of bacteria capable of utilizing sucrose. In a ground-breaking approach, we harnessed the potential of sugar beet molasses, a by-product rich in sucrose, amino acid, and vitamins, as a growth medium for this purpose. Through meticulous investigation, we identified the ideal conditions for maximizing ectoine synthesis.
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