[New trends in antimicrobial therapy of chronic purulent mesotympanitis].

Antibiotic therapy with colbiocin of chronic purulent mesotympanitis achieved a response rate of 92%, recurrence-free interval reached 6 months in 84% of the treated patients. This allows to recommend colbiocin as a drug of choice in hospital and outpatient treatment of chronic purulent mesotympanitis.

[The effect of antidepressants on the indices of the cardiointervalogram in intact rats and during the deprivation of paradoxical sleep].

The acute and chronic administration of antidepressants (amitriptyline, imipramine, befol) to rats led to the sympathetic influences of a cardiointervalogram as reduced cardiointervals and its increased amplitude and tension index. Imipramine was found to be effective in eliminating disadaptational abnormalities in cardiac performance, which promoted REM-sleep deprivation.