Metal concentrations, oxidative status and histopathological evaluation of fish species from Doce River, Brazil, after the Fundao dam collapse.

Eight years after the tailings dam collapse in Mariana, MG, Brazil, several aspects of this massive disaster are yet to be elucidated. Our goal was to investigate the impact of the mud flow on 16 fish species collected across 15 points from the Doce River, addressing 12 metal concentrations, tissue oxidative status (antioxidant enzymes and stress biomarkers), and histopathological analyses. The species Trachelyopterus striatulus, Prochilodus vimboides, Loricariichthys castaneus, Lophiosilurus alexandri, Hypostomus affinis, Hoplias intermedius were shown to be the most affected regarding the gills tissue integrity; Hypostomus affinis, Oligosarcus acutirostris, Lophiosilurus alexandri, Pygocentrus nattereri, Hoplosternum littorale, and Loricariichthys castaneus showed the highest levels of liver health.

Low oral health literacy, dental caries, and school features are associated with reasons for seeking dental services among adolescents.

Objective: The present study aimed to investigate associations between reasons for seeking dental services, considering the last dental appointment of adolescents, and their educational features, socioeconomic and oral health status, and oral health literacy.

Methods: A cross-sectional study was conducted with 746 adolescents aged 15-19 years in Campina Grande (Paraíba), Brazil. Parents/guardians answered a socioeconomic questionnaire.

The disability profile in primary care may depend on the type of care and pain aspects.

To investigate the relationship between sociodemographic factors, musculoskeletal pain and its characteristics, and the type of primary health care received with self-reported disability. This is a cross-sectional study, interviewing individuals selected from spontaneous demand for health care in two types of care: health center and family health unit. Disability was investigated using the World Health Organization Disability Assessment Schedule (WHODAS) 2.

Steroid-Resistant Nephrotic Syndrome Is Associated With a Unique Genetic Profile in a Highly Admixed Pediatric Population.

Introduction: The profile of genetic and nongenetic factors associated with progression to kidney failure (KF) in steroid-resistant nephrotic syndrome (SRNS) is largely unknown in admixed populations.

Methods: A total of 101 pediatric patients with primary SRNS were genetically assessed targeting Mendelian causes and status with a 62-NS-gene panel or whole exome sequencing, as well as genetic ancestry. Variant pathogenicity was evaluated using the American College Medical of Genetics and Genomics (ACMG) criteria.