Publications by authors named "F Ntchapda"
3,3'4-trimethoxy-4'-rutinosylellagic acid and its acetylated derivative: Antioxidant activity and antiproliferative effects on breast cancer cells and molecular docking study.
Biomed Pharmacother
October 2024
Article Synopsis
- - The study investigates two natural compounds, TR2 and TR22, for their potential antioxidant and anticancer properties against two types of breast cancer cells (estrogen-sensitive MCF-7 and non-sensitive MDA-MB 231).
- - TR2 demonstrated stronger antioxidant effects compared to standard antioxidants and effectively inhibited the growth and migration of breast cancer cells, while TR22 showed a more significant proliferation inhibition following acetylation.
- - Molecular docking studies indicated that both compounds could inhibit receptor tyrosine kinases, suggesting their potential as effective agents in slowing cancer progression.
Backgroud: is a herbaceous plant used in traditional Cameroonian medicine to treat diabetes mellitus. The aim of this study was to evaluate the antidiabetic properties of the aqueous extract of leaves (AEEF) in diabetic rats.
Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg) in normal rats fasted for 16 h.
Diabetes mellitus (DM) is one of the leading worldwide public health problems. It is characterized by hyperglycemia which induces oxidative stress and inflammation, both involved in the pathogenesis of diabetes. We previously showed that (BD) and (HS) extracts reduced hyperglycemia and hyperlipidemia in alloxan-induced diabetic rats.
View Article and Find Full Text PDFPotential Curative Effects of Aqueous Extracts of (Vitaceae) and (Euphorbiaceae) on Acetaminophen-Induced Liver Injury in Mice.
Curr Ther Res Clin Exp
September 2023
Background: Acetaminophen-induced liver injury remains a significant public health problem because available treatments are limited due to their adverse effects. Medicinal plants, which are an important source of bioactive molecules, could be an alternative treatment for liver disease.
Objective: This study was designed to investigate the curative effect of aqueous extracts of (Vitaceae) and (Euphorbiaceae) on acetaminophen-induced liver injury in mice.
Background And Aim: African traditional healers use Blume to treat diseases such as diabetes mellitus, malaria, dysentery, constipation, and hemorrhoids. This study aimed to assess the hypoglycemic, lipid-lowering, and antioxidant properties of extract (AERS) in type 1 diabetic (T1D) and insulin-resistant (T2D) rats.
Experimental Procedure: The induction of T1D was made by intraperitoneal administration of streptozotocin (55 mg/kg b.