Publications by authors named "F Nozzoli"
Article Synopsis
- The study investigates post-COVID-19 (PC) and post-COVID-19 vaccination (PCV) syndromes, specifically focusing on small fiber neuropathy (SFN) and its potential link to undifferentiated arthritis (UA).
- Nineteen patients with possible SFN underwent several diagnostic tests, including skin biopsies and joint ultrasounds, to evaluate symptoms like severe lower limb paresthesia and to compare SFN positive (SFN+) versus negative (SFN-) patients.
- Results showed that SFN+ patients had lower nerve fiber density and more abnormalities in imaging tests. Over 12 months, SFN+ patients reported decreased neurological symptoms and improved joint assessments, although nerve density did not significantly change.
Brightfield Multiplex Immunohistochemistry Assay for PD-L1 Evaluation in Challenging Melanoma Samples.
Appl Immunohistochem Mol Morphol
September 2024
Article Synopsis
- Targeting the PD1/PD-L1 immune checkpoint pathway has become a key treatment strategy for melanoma patients, with PD-L1 expression testing becoming essential for access to immunotherapy.
- Current methods for evaluating PD-L1 in melanoma samples face significant challenges despite increasing demand and experience in the field.
- This technical report introduces and validates a double staining protocol for PD-L1/SOX10 that enhances the ability to clearly identify PD-L1 positive melanoma cells and encourages further research on its practical applications and consistency across different pathologists.
Cutaneous squamous cell carcinoma (cSCC) stands as the second most prevalent non-melanoma skin cancer worldwide, comprising approximately 20% of all cutaneous malignancies. Determining its precise incidence poses challenges; however, reports indicate a global increase in its prevalence. At the time of diagnosis, the majority of cSCCs are localized, resulting in favorable 5-year cure rates surpassing 90%.
View Article and Find Full Text PDFBackground: Perineural invasion (PNI) is a complex molecular process histologically represented by the presence of tumor cells within the peripheral nerve sheath and defined when infiltration into the 3 nerve sheath layers can be clearly identified. Several molecular pathways have been implicated in cSCC. PNI is a well-recognized risk factor in cutaneous squamous cell carcinoma (cSCC) and its accurate assessment represents a challenging field in pathology daily practice.
View Article and Find Full Text PDFPrecision measurements by the Alpha Magnetic Spectrometer (AMS) on the International Space Station of the deuteron (D) flux are presented. The measurements are based on 21×10^{6} D nuclei in the rigidity range from 1.9 to 21 GV collected from May 2011 to April 2021.
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