Publications by authors named "F Novak"
Humoral and cellular immune response from first to fourth SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients-a longitudinal cohort study.
Front Immunol
September 2024
Article Synopsis
- This study investigates how patients with multiple sclerosis (MS) on anti-CD20 therapy respond to multiple doses of the BNT162b2 mRNA COVID-19 vaccine and the incidence of breakthrough infections.
- It found that the percentage of participants with antibodies increased significantly after the fourth vaccine dose, but a majority still experienced breakthrough infections during the study.
- The study concluded that while antibody levels increased post-vaccination, T-cell responses remained stable and were not affected by breakthrough infections.
Background: This study investigates clinical and biomarker differences between standard interval dosing (SID) and extended interval dosing (EID) of ocrelizumab therapy in multiple sclerosis (MS).
Methods: This is a prospective, double-arm, open-label, multi-center study in Denmark. Participants diagnosed with MS on ocrelizumab therapy >12 months were included ( = 184).
Introduction: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years.
Methods: National registry data were collected using a standardised online form based on the OASIS registry (Oley - A.
(1) Objectives Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status and liver function markers in HPNPs. (2) Methods: Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks.
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